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ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

Recruitingn/aAges 18 Years - anyAllargenx
NCT07294170 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Is at least 18 years of age and the local legal age of consent for clinical studies * Has been diagnosed with MG with consistent clinical features per the investigator's clinical judgment * If receiving MG therapy, including nonsteroidal immunosuppressive drugs (NSIDs), corticosteroids, or acetylcholinesterase (AChE) inhibitors either in combination or alone, the participant should receive a stable dosage before master protocol screening Exclusion Criteria: * Known autoimmune disease or any medical condition other than the indication under study that would interfere with an accurate assessment of clinical symptoms of MG or puts the participant at undue risk * Is MGFA (Myasthenia Gravis Foundation of America) Class V
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What it tests

  • Efgartigimod IV
  • Empasiprubart IV
  • Placebo IV
  • Efgartigimod PH20 SC PFS
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Where

37 sites
Profound Research LLC - Carlsbad
Carlsbad, United States
Visionary Investigators Network
Miami, United States
Visionary Investigators Network
Miami, United States
University of South Florida
Tampa, United States
Massachusetts General Hospital
Boston, United States
Henry Ford Health System
Detroit, United States
Profound Research LLC at Las Vegas Neurology Center
Las Vegas, United States
Dent Neurologic Institute - Amherst
Amherst, United States

…and 29 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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