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Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

RecruitingEARLY Phase 1Ages 18 Years - anyAllCase Western Reserve University
NCT07298057 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adults (≥18 years) with type 2 diabetes mellitus (HbA1c ≥ 7.0% and ≤9.5%) 2. Diagnosed with moderate to severe periodontitis (≥5 mm probing pocket depth in at least 6 distinct interproximal sites, on different teeth) 3. At least 16 teeth present 4. No periodontal treatment in the last 6 months Exclusion Criteria: 1. Allergy to minocycline or tetracycline 2. Unable to receive or to tolerate local anesthesia 3. Unable to tolerate tooth instrumentation with ultrasonic instruments. 4. Require IV sedation to receive scaling and root planing 5. Use of antibiotics within the past 3 months 6. Pregnancy or breastfeeding 7. Morbid Obesity (BMI 40+) 8. Smokers or patients with poorly controlled systemic diseases other than diabetes
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What it tests

  • local antibiotic application of topical minocycline
  • Scaling and Root Planing
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Where

1 site
Case Western Reserve University
Cleveland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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