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Effect of Magnesium and Levocarnitine on Metabolic and Clinical Outcomes in Women With Polycystic Ovarian Syndrome (PCOS)

RecruitingNAAges 19 Years - 65 YearsFemaleBehnood Abbasi
NCT07298564 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age and is associated with metabolic abnormalities such as insulin resistance, dyslipidemia, and hormonal imbalance, which may lead to infertility and hirsutism. Despite the availability of several pharmacological treatments, many therapies fail to effectively address the underlying metabolic and endocrine dysfunctions of PCOS. Magnesium and L-carnitine are two essential nutrients that may play a synergistic role in improving insulin sensitivity, glucose metabolism, and lipid profile, as well as reducing oxidative stress and androgen production in women with PCOS. This randomized, triple-blind, placebo-controlled clinical trial aims to evaluate the effects of co-supplementation with magnesium and L-carnitine on glycemic control indices, lipid profile, and hirsutism in women with PCO

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 19 and 65 years. * Diagnosis of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria. Exclusion Criteria: * Hypothyroidism * Menopause * Pregnancy or breastfeeding * Renal (kidney) dysfunction * Use of therapeutic vitamin or mineral supplements * Liver diseases (e.g., grade 3 fatty liver, hepatitis, or cirrhosis) * Psychiatric disorders such as bipolar disorder * Neuromuscular diseases (e.g., myasthenia gravis, Parkinson's disease, multiple sclerosis, epilepsy, or muscular dystrophy) * History of seizures * Participants who become pregnant during the study or fail to comply with more than 20% of the study protocol will be withdrawn from the study
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What it tests

  • Magnesium 500 mg
  • Levocarnitine 1000 mg
  • Placebo
  • Magnesium 500 mg
  • Placebo Levocarnitine
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Where

1 site
Tara Momeni
Tehran, Iran
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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