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Effect of Whey Protein Versus Egg Albumen Protein Challenge on Blood Ammonia Level in Patients of Decompensated Ethanol Related Cirrhosis.

RecruitingNAAges 18 Years - 70 YearsAllInstitute of Liver and Biliary Sciences, India
NCT07299110 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In cirrhosis, altered nitrogen metabolism and reduced hepatic clearance of ammonia contribute to the development of Minimal Hepatic Encephalopathy (MHE)-a subclinical but functionally debilitating condition. While adequate protein intake is essential to prevent sarcopenia in cirrhotic patients, the type of protein consumed can significantly influence postprandial ammonia generation, thereby affecting neurocognitive status. This study investigates the differential ammoniagenic potential of two commonly used high-protein nutritional supplements-Whey protein, which is rich in branched-chain amino acids (BCAAs) and rapidly absorbed, and egg albumen protein, which is slower digesting and higher in aromatic amino acids (AAAs), potentially more ammoniagenic. In a crossover pilot design, 50 patients with decompensated ethanol-related cirrhosis will undergo two separate standardized protein cha

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Known or newly diagnosed (clinical, imaging) case of decompensated ethanol related cirrhosis patients. 2. Age (18-70 years). 3. Informed consent to participate in the study. Exclusion Criteria: 1. History of overt HE (West Haven grade II or more). 2. Last Intake \<1.5 months. 3. CKD (creatinine \>1.5 mg/dL), active infection, GI bleeding in past 2 weeks. 4. Severe anaemia (Hb \<7 g/dL) or hypoalbuminemia (\<2.0 g/dL). 5. Known egg or dairy allergy. 6. Those on sedatives, antidepressant or anti-psychiatric medication. 7. Unable to understand the language or instructions. 8. Hepatocellular Carcinoma. 9. TIPS. 10. Receiving rifaximin or lactulose. 11. Diarrhea, SIBO or malabsorptive syndrome.
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What it tests

  • Whey Protein
  • Egg Albumen
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Where

1 site
Institiute of liver and biliary sciences
New Delhi, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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