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Biological Determinants and Neural Compensation of Dysphagia in Parkinson's Disease

Recruitingn/aAges 18 Years - anyAllHeinrich-Heine University, Duesseldorf
NCT07299448 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Parkinson's disease (PD) is the second most common neurodegenerative disorder and frequently leads to oropharyngeal dysphagia, a swallowing disorder that strongly affects patient health and quality of life. Dysphagia in PD is associated with aspiration pneumonia, malnutrition, and impaired medication intake, which together represent one of the leading causes of morbidity and premature mortality in these patients. Despite its clinical relevance, the underlying biological mechanisms of dysphagia in PD are not fully understood, and current treatment strategies are limited. The purpose of this study is to investigate the clinical, biological, and neural determinants of oropharyngeal dysphagia in patients with PD, and to explore compensatory mechanisms of the brain that may counteract swallowing difficulties. We hypothesize that dysphagia in PD is linked not only to disease severity and prog

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📋 Eligibility rules (as published)
Inclusion Criteria: .- Patients with idiopathic Parkinson's disease diagnosed according to the MDS diagnostic criteria * Participation possible in all disease stages, regardless of the presence or absence of subjective or objective oropharyngeal dysphagia * Cognitive ability sufficient to comply with the study paradigm * Daily oral intake of food and fluids (exclusion of patients with exclusive tube feeding) Exclusion Criteria: * Presence of other conditions associated with oropharyngeal dysphagia, such as stroke, head and neck cancer, neuroinflammatory diseases, neuromuscular disorders, or other brain injuries * Presence of electronic stimulation devices (e.g., pacemaker, deep brain stimulation) or other contraindications for MRI imaging * Diagnosis of asthma or COPD (due to performance of the cough reflex test in "Block 1: Assessment of OD and pharyngeal hyposensitivity")
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What it tests

  • Not listed
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Where

1 site
University Hospital Düsseldorf
Düsseldorf, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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