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Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip Infection: a Microdialysis Study

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Bonn
NCT07299591 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to use the technique of microdialysis to analyse the intraarticular space of the hip joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing cement spacer over the entire period of the first hospitalization (usually 14 days) to closely monitor pharmacological and immunological aspects. In detail, antibiotic concentrations in the joint cavity and systemic circulation will be assessed according to reinfection rates, infection-free survival and fucntional outcome over a 12-month folluw-up period.

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📋 Eligibility rules (as published)
Inclusion Criteria: * clinical indication for two-stage revision of hip PJI * approval for surgery by the orthopedic and anesthesiologic department * being over 18 years of age * written, informed consent after detailed patient information about the study protocol and possible study dependent risks Exclusion Criteria: * \- known allergies to antibiotics gentamicin and vancomycin used within the spacer
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What it tests

  • Not listed
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Where

1 site
University Hospital Bonn
Bonn, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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