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Efficacy and Safety of Intravenous Thrombolysis in Branch Atheromatous Disease

Recruitingn/aAges 18 Years - anyAllSigmund Freud PrivatUniversitat
NCT07299994 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rationale and Relevance: Branch Atheromatous Disease (BAD) describes an atherosclerotic occlusion of one of the deep penetrating cerebral arteries, including the lenticulostriate artery (LSA), paramedian pontine artery (PPA), and anterior choroidal artery (ACHA). BAD is frequently associated with early neurological deterioration (END), particularly progressive motor deficits that contribute to increased disability. Despite its clinical relevance, BAD remains underrepresented in major radiomorphological classification systems such as TOAST, which has led to limited evidence and unclear treatment strategies. Previous studies suggest that the efficacy of intravenous thrombolysis (IVT) may be reduced in BAD compared to other stroke etiologies. Objectives: The primary objective of this study is to evaluate the efficacy and safety of IVT compared with single antiplatelet therapy (SAPT) and

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📋 Eligibility rules (as published)
Inclusion Criteria: * aged over 18 years, with acute ischemic stroke and symptom onset no more than 24 hours before admission, who were treated in one of the stroke units of the participating institutions. * All enrolled patients must have undergone a cerebral MRI for inclusion: 1. DWI lesion: single isolated deep subcortical stroke AND 2. The affected vessel involves the LSA, PPA, or ACHA, and the infarct lesion on DWI conforms to one of the following characteristics (A, B, OR C): A. LSA: "Comma-like" infarct lesions with "fan-shaped" extension from bottom to top in the coronary position OR ≥ 3 layers (layer thickness 5 mm) on axial DWI. B. PPA: Infarct lesion extending from the deep pons to the ventral pons on axial DWI. C. ACHA: Infarct within the anterior choroidal artery territory. Exclusion Criteria: * Typical recent small subcortical infarction (RSSI) (oval, \<20mm in all axes) * ≥ 50% stenosis on the parent artery (i.e., BA, MCA, or ICA) * Stroke due to other clearly identified causes or possible cardioembolic etiology.
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What it tests

  • Not listed
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Where

8 sites
Clinic Favoriten
Vienna, Austria
Clinic Hietzing
Vienna, Austria
Department of Neurology, St. John's Hospital, Vienna, Austria
Vienna, Austria
Department of Neurology, Medical University of Vienna
Vienna, Austria
Department of Neurology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin
Berlin, Germany
Department of Neurology, Heidelberg University Hospital
Heidelberg, Germany
Department of Neurology & Stroke, University of Tübingen
Tübingen, Germany
Department of Neurology, Universityhospital of Bern
Bern, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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