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Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers

RecruitingNAAges 18 Years - 65 YearsAllAlexandria University
NCT07300735 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a comparative interventional study to determine the best way to prevent G-CSF induced bone pain in patients with hematological malignancies (blood cancers). G-CSF (Granulocyte Colony-Stimulating Factor) is a drug commonly used in these patients to boost white blood cell production, but it frequently causes severe bone pain. The study is comparing two oral medications for their effectiveness as a preventive treatment: * Diosmin-Hesperidin (a flavonoid supplement). * Loratadine (a common anti-allergy medication). The core question the study is trying to answer is: * Is diosmin-hesperidin effective in preventing G-CSF-induced bone pain compared to loratadine? * Does the combination of diosmin-hesperidin and loratadine offer better pain prevention than either drug alone?

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults 18 to 65 years old * Receiving a G-CSF for one of the following indications: Treatment of neutropenia along with treatment for leukemia or lymphoma Neutropenia prevention following autologous hematopoietic cell transplant * Patients with or without bone pain associated with G-CSF administration. * Willingness to provide informed consent to participate in the study. Exclusion Criteria: * Patients with solid tumors. * Pregnant or breastfeeding women. * Patients with known allergies or hypersensitivity to Loratadine, Diosmin- Hespiridin or Filgrastim. * Patients with pre-existing bone disorders or receiving bone modifying agents * Chronic use of antihistamines, Diosmin-Hespiridin, NSAIDs, corticosteroids, or immunosuppressants. * Receiving medications with drug interaction grade X with Loratadine, Diosmin-Hespiridin or Filgrastim * Patients who are unable to understand or provide informed consent
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What it tests

  • Loratadine
  • Diosmin-Hesperidin
  • Loratadine + Diosmin-Hesperidin
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Where

1 site
Alexandria University Hospitals
Alexandria, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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