💬In plain words
What the trial is, and whether it could suit you
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers. Historical data indicate that 55% of heavy smokers will die from cardiovascular disease (CVD), while approximately 5% will die from lung cancer. Lung cancer screening programs are currently being implemented worldwide, but efforts to reduce also CVD are not included.
The research group behind the ACE 5 Study are affiliated with the study team behind the implementation study of lung cancer screening in Norway ("Tidlig oppdagelse av lungekreft \[TIDL\]"). The TIDL Study have performed non-contrast, non-cardiac chest CT-based screening for lung cancer in 1000 individuals. Prior studies have demonstrated that a visual four-group classification of coronary artery calcification using non-contrast, non-cardiac chest CT images provide an easily available, n
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria used for the lung cancer screening implementation study/ TIDL Study:
* Women and men
* Ages 60 to 79 years old (inclusive)
* A smoking history of at least 35 pack-years and 1) being a current smoker or a former smoker who quit less than 10 years prior or 2) having a PLCOm2012 model 6-year risk for lung cancer incidence over 2.6%.
* Willingness and ability to comply with scheduled visits, laboratory tests, and other trial procedures
* Written informed consent obtained prior to performing any protocol-related procedures
* The participant should be affiliated to a social security system
Exclusion Criteria used for the lung cancer screening implementation study/ TIDL Study:
* Recent abnormal pulmonary findings under work-up of standard care
* Having had chest CT \<1 year before potential entry into the study
* Current or prior history of lung cancer, renal cancer, melanoma or breast cancer
* Inability to provide signed informed consent
* Insufficient understanding of the languages in which trial information is available
* Psychiatric or other disorders that are incompatible with compliance to the protocol requirements and follow-up
* Unable to be followed-up for at least 5-years
* Body weight \>140 Kg because of difficulty of conducting the CT exam
Inclusion Criteria used for the ACE 5 Study:
* Participants from the TIDL Study with non-contrast, non-cardiac chest CT images available as part of the implementation lung cancer screening study
* Signed consent for cardiovascular add on-study and agree to protocol, including follow-up visit 1-year after the baseline examination
Exclusion Criteria used for the ACE 5 Study:
* Any surgical or medical condition, including short life-expectancy, based on medical records or clinical findings prior to randomization, that will impair the ability of the patient to participate in the study
* Patients unwilling or unable to comply with the protocol
* History of non-compliance to medical management and patients who are considered potentially unreliable, based on information obtained prior to randomization
* History or evidence of alcohol or drug abuse with the last 12 months, based on information obtained prior to randomization, that will influence study participation
💊
What it tests
- Lung Cancer Screening Plus Program
- Standard of Care
Akershus University Hospital
Lørenskog, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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