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Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG

RecruitingNAAges 18 Years - anyAllChina National Center for Cardiovascular Diseases
NCT07302659 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically: This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (\>18 years old) with multivessel coronary artery disease who are scheduled to undergo isolated off-pump coronary artery bypass grafting and who provide informed consent to participate in this study. Exclusion Criteria: * Indications for cardiopulmonary bypass surgery (or no contraindications to on-pump surgery); * Great saphenous vein is unsuitable for use as a graft conduit; * Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit; * History of previous cardiac surgery; * Emergency surgery; * Inability to apply an aortic clamp due to severe ascending aortic calcification; * Expected inability to tolerate MRI or contraindications to MRI (e.g., known intolerance to MRI, an implanted permanent pacemaker, or an anticipated need for permanent pacemaker implantation); * Inability to complete neurocognitive assessment due to language barriers or visual/hearing impairment.
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What it tests

  • Aortic no-touch coronary artery bypass grafting (RIMA-SVG)
  • Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)
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Where

4 sites
Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, China
Peking University First Hospita
Beijing, China
Qingdao Cardiovascular Hospital
Qingdao, China
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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