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Effects of Exercise and Sleep on Motor Learning and Functional Abilities in Multiple Sclerosis

RecruitingNAAges 18 Years - 70 YearsAllZealand University Hospital
NCT07304375 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The ExSiMS study is a randomized, controlled crossover study including 20 individuals (18-70 years) diagnosed with relapsing remitting Multiple Sclerosis (MS) This project investigates, through behavioral and neurophysiological measurements, how aerobic exercise on an ergometer bike and sleep in the form of a nap and overnight sleep may enhance cortical motor skill learning evaluated by a complex hand motor skill test and thereby improve functional capacity in individuals with MS. Beyond the effect on motor skill learning, the project investigate the effect on electroencephalography (EEG) - electromyography (EMG) coherence. The study hypothesizes that individuals with neurological conditions, such as multiple sclerosis (MS), may experience beneficial effects on specific motor rehabilitation through systematically planned cardiovascular exercise and sleep scheduling, due to positive impa

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📋 Eligibility rules (as published)
Inclusion Criteria: * Competent individuals (aged 18-70) diagnosed with early relapsing-remitting MS * Expanded Disability Status Score, 1 \< EDSS \< 4.5 * MRC muscle strength ≥ 4+ in the dominant hand Exclusion Criteria: * Implanted devices, such as pacemakers or stimulators * Epilepsy or neuromuscular diseases
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What it tests

  • Aerobic Exercise
  • Daytime Sleep - Nap
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Where

2 sites
Section of Movement and Neuroscience, Department of Nutrition, Exercise, and Sports, University of Copenhagen
Copenhagen, Denmark
Zealand University Hospital Roskilde
Roskilde, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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