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Effect of Menstrual Phase on the Anesthetic Efficacy

RecruitingNAAges 18 Years - 45 YearsFemaleJamia Millia Islamia
NCT07306533 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational prospective clinical study is to learn whether the menstrual phase influences the anesthetic efficacy of inferior alveolar nerve block (IANB) in female patients aged 20-40 years with symptomatic irreversible pulpitis in mandibular molars. The main questions it aims to answer are: Does the success rate of IANB vary across different phases of the menstrual cycle? Are certain menstrual phases associated with a higher likelihood of anesthetic failure during endodontic access preparation? Researchers will compare five menstrual phase groups (menstrual, follicular, ovulatory, luteal, and premenstrual) to see if hormonal fluctuations affect anesthetic success. Participants will: Receive a standardized inferior alveolar nerve block using 2% lidocaine with 1:80,000 epinephrine Undergo cold testing and access cavity preparation to assess anesthetic success Hav

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📋 Eligibility rules (as published)
Inclusion Criteria * Female patients aged 20-40 years. * Regular menstrual cycles (28 ± 3 days). * Diagnosed with symptomatic irreversible pulpitis in mandibular molars. * Indicated for root canal therapy. * Willing to provide informed consent. Exclusion Criteria * Use of oral contraceptives or hormonal therapy. * Irregular menstrual cycles. * Pregnancy or lactation. * Systemic disease affecting pain perception (e.g., diabetes, neuropathies). * Recent use of analgesics or sedatives (within 24 hours). * Allergy to local anesthetics.
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What it tests

  • Inferior Alveolar Nerve Block
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Where

1 site
Faculty of Dentistry, JMI
New Delhi, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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