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Sucrase-Isomaltase (SI) Genes and Meal Load

RecruitingNAAges 18 Years - 70 YearsAllRegion Skane
NCT07309601 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this interventional study is to examine whether those patients with irritable bowel syndrome (IBS) and a reduced abitility do degrade starch and sugar (lowe levels of enzymes) have lower raise in blood glucose after a meal than those with normal expression of enzymes. We also want to examine whether those IBS patients with reduced enzyme levels have increased bowel symptom in relation to this meal. The main questions it aims to answer are: Does reduced ability to degrade starch and sugar due to less enzyme activity lead to lower increase in blood glucose after a meal? Does reduced ability to degrade starch and sugar due to less enzyme activity lead to increased bowel symptoms after a meal?

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of irritable bowel syndrome (IBS) * Gene testing has been conducted regarding genes regulating the production of sucrase-isomaltase ensymes in previous dietary interventions using the starch- and sucrose reduced diet (SSRD) or multi-center study. Exclusion Criteria: * Diagnosis of inflammatory bowel disease, celiac disease, bile salt malabsorption, gastroenteritis or enteric dysmotility * Severe food allergy * Serious heart-, lung-, cardiovascular-, malignant- or mental illness * Ongoing eating disorder * Pregnancy * Recent major gastrointestinal surgery * Alcohol and/or drug addiction
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What it tests

  • Meal load
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Where

1 site
Skåne University Hospital
Malmö, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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