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MPR for Stroke Risk Assessment of ICAS

Recruitingn/aAges 18 Years - 80 YearsAllXuanwu Hospital, Beijing
NCT07309718 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adults aged 18 to 80 years. 2. Intracranial atherosclerotic stenosis ICAS involving a culprit artery in the anterior circulation. 3. Intracranial arterial stenosis of 50% to 99% as measured by the WASID method using TCD, CTA, MRA, or DSA. 4. Written informed consent obtained from the participant or a legal representative. Exclusion Criteria: 1. Non-atherosclerotic intracranial lesions, including moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital/genetic abnormalities. 2. More than 50% stenosis of the extracranial carotid artery on the ipsilateral side. 3. Large cerebral infarction involving more than one-half of the territory on DWI imaging, or a baseline modified Rankin Scale score ≥3. 4. Contraindications to antiplatelet therapy or statins. 5. Inability to undergo MRI due to metal implants or claustrophobia.
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What it tests

  • Standardized medical therapy targeting vascular risk factors and stroke prevention
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Where

1 site
Department of Neurosurgery, Xuanwu hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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