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โ† Trials
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Lung EIT Image Guide Ventilation in ARDS

RecruitingNAAges 18 Years - anyAllPeking Union Medical College Hospital
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In plain words

What the trial is, and whether it could suit you

The goal of this multi-center randomized controlled clinical trial is to learn if an individualized, bedside electrical impedance tomography (EIT)-guided ventilation strategy (including EIT-guided prone positioning and PEEP titration) can improve outcomes compared with a conventional lung-protective ventilation strategy in adult patients with acute respiratory distress syndrome (ARDS). The main questions it aims to answer are: Does the individualized EIT-guided ventilation strategy reduce 28-day mortality in ARDS patients? Researchers will compare the EIT-guided intervention arm to a control arm receiving routine lung-protective ventilation (without bedside EIT guidance) to see if the EIT-guided approach lowers 28-day mortality and improves other clinical outcomes. Adult ARDS patients who meet inclusion criteria will be assigned to EIT-guided group and control group through stratified

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients with ARDS receiving mechanical ventilation who meet the following diagnostic criteria: 1. Triggered by acute risk factors such as pneumonia, non-pulmonary infection, trauma, transfusion, aspiration, or shock. Pulmonary edema is not entirely or predominantly attributable to cardiogenic causes or fluid overload, and hypoxemia/gas exchange impairment is not mainly due to atelectasis. However, ARDS can be diagnosed in the presence of these conditions if predisposing risk factors exist. 2. Acute onset or worsening of hypoxemic respiratory failure within 1 week of the identified risk factor or onset of new or worsening respiratory symptoms. 3. Bilateral opacities on chest radiograph or CT, or bilateral B-lines and/or consolidation on ultrasound, not fully explained by effusion, atelectasis, or nodules/masses. 4. PaOโ‚‚/FiOโ‚‚ โ‰ค 300 mm Hg or SpOโ‚‚/FiOโ‚‚ โ‰ค 315 (if SpOโ‚‚ โ‰ค 97%). * ARDS onset within 1 week. * Mechanical ventilation โ‰ค 72 hours. Exclusion Criteria: * Age \< 18 years. * Pregnancy. * Contraindications to EIT application (e.g., local skin lesions, cardiac pacemaker). * Contraindications to prone positioning (e.g., increased intracranial pressure, intra-abdominal hypertension, spinal fractures). * Evidence of barotrauma such as pneumothorax, mediastinal emphysema, or subcutaneous emphysema. * End-stage disease. * Informed consent not signed by legal guardians or family.
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What it tests

  • Recruitment maneuver and PEEP setting guided by EIT
  • PEEP setting according to routine practice
  • Prone positioning guided by EIT
  • Prone positioning according to routine practice
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Where

1 site
Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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