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Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs

Recruitingn/aAges any - anyAllSt. Antonius Hospital
NCT07309848 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting longer can also increase risks such as complications and longer hospital stays. The purpose of this study is to find out whether operating within 24 hours is as safe as delaying surgery beyond 24 hours. Specifically, the investigators want to know if early surgery does not lead to a higher need for blood transfusions compared to delayed surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Isolated hip fracture classified as AO/OTA 31A or 31B requiring surgical intervention. * Current DOAC use with the last dose taken ≤24 hours before emergency department (ED) presentation Exclusion Criteria: * Pathologic or periprosthetic hip fractures. * Fracture sustained \>24 hours before ED presentation. * Inter-hospital transfer. * Hematologic disorders (e.g., thalassemia, sickle cell disease, aplastic anemia, myelodysplastic syndromes, leukemia). * Use of a non-EMA-approved DOAC (e.g., betrixaban).
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What it tests

  • Not listed
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Where

7 sites
Ziekenhuisgroep Twente Hospital
Almelo, Netherlands
Onze Lieve Vrouw Gasthuis Hospital
Amsterdam, Netherlands
Rijnstate Hospital
Arnhem, Netherlands
Deventer Hospital
Deventer, Netherlands
Martini Hospital
Groningen, Netherlands
Diakonessenhuis Hospital
Utrecht, Netherlands
St. Antonius Hospital
Utrecht, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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