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External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients

Recruitingn/aAges 18 Years - anyAllInfanta Leonor University Hospital
NCT07310693 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to externally validate the CLOVER score, a machine learning-based predictive model designed to identify patients with venous thromboembolism (VTE) who are at increased risk of having an occult cancer. The study includes a retrospective cohort of patients with acute symptomatic VTE diagnosed between 2000 and 2022, and a prospective cohort of consecutively recruited patients from December 2025 to December 2027. The CLOVER model will be applied to all participants, and its ability to discriminate between patients with and without occult cancer will be evaluated. The study also assesses clinicians' satisfaction with the web-based tool (CLOVER-Web) developed to facilitate the use of the score in clinical practice.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years. * Objectively confirmed acute symptomatic venous thromboembolism (deep vein thrombosis and/or pulmonary embolism). * Ability to provide written or electronic informed consent. Exclusion Criteria: * Suspicion of cancer during the initial diagnostic evaluation for VTE. * Participation in another interventional study that may interfere with outcomes. * Inability or refusal to provide informed consent.
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What it tests

  • Not listed
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Where

12 sites
Hospital Clínic
Barcelona, Spain
Hospital Universitario Infanta Leonor
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Príncipe de Asturias
Madrid, Spain
Hospital Universitatio del Sureste
Madrid, Spain
Hospital Universitario de Móstoles
Madrid, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, Spain
Hospital Universitario Morales Meseguer
Murcia, Spain

…and 4 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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