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HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy

Recruitingn/aAges 18 Years - 65 YearsAllÖmer Faruk Okumuş
NCT07312045 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational clinical study aims to investigate the relationship between the HALP score (Hemoglobin × Albumin × Lymphocyte / Platelet), several blood-based inflammatory indices (including NLR, PLR, LMR, and SII), and salivary MMP-8 levels in individuals with periodontal health, gingivitis, and stage III/IV periodontitis. The study also evaluates how these biomarkers relate to healing following non-surgical periodontal therapy. A total of 180 participants aged 18-65 years will be included: 50 healthy individuals, 50 patients with gingivitis, and 80 patients with stage III/IV periodontitis. All participants will undergo periodontal clinical examination and provide blood and saliva samples at baseline. Individuals in the gingivitis and periodontitis groups will receive standard non-surgical periodontal treatment (full-mouth debridement) and will return for a 3-month follow-up visit,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18-65 years * Ability to provide informed consent * No systemic diseases or conditions affecting periodontal status * For Healthy Group: Probing depth ≤3 mm, no attachment loss, no radiographic bone loss * For Gingivitis Group: Gingival inflammation and bleeding on probing without attachment loss or bone loss * For Periodontitis Group: Stage III or stage IV periodontitis according to 2018 classification * No periodontal treatment within the past 6 months * Willingness to attend follow-up visits Exclusion Criteria: * Systemic diseases influencing periodontal inflammation (e.g., diabetes, autoimmune disorders) * Current pregnancy or lactation * Use of antibiotics, anti-inflammatory medications, or immunosuppressive drugs within the last 3 months * Smokers or individuals using tobacco products * History of periodontal surgery in the last 6 months * Presence of fewer than 20 natural teeth * Any condition that may interfere with study participation or data reliability
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What it tests

  • Non-surgical Periodontal Therapy
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Where

1 site
Erzincan Binali Yıldırım University Faculty of Dentistry
Merkez, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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