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EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS

RecruitingNAAges 18 Years - 90 YearsAllNguyen Dang Thu
NCT07313644 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery. Mechanical ventilation is essential for supportive care in this population, but may aggravate lung injury when suboptimal ventilatory settings are applied. Positive end-expiratory pressure (PEEP) is crucial for maintaining alveolar recruitment; however, optimal PEEP selection in trauma- or postoperative-associated ARDS remains uncertain. Electrical impedance tomography (EIT) enables bedside, real-time assessment of regional ventilation and may support optimal PEEP titration by balancing alveolar overdistension and collapse. This study compares EIT-guided PEEP optimization with the conventional low FiO₂-PEEP strategy in terms of oxygenation and respiratory mechanics in patients with moderate to severe ARDS following trauma or surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS. Exclusion Criteria: * Age \<18 or \>90 years. * Severe acute brain injury or acute stroke with Glasgow Coma Scale \<8. * Thoracic trauma with pneumothorax or pneumomediastinum. * End-stage diseases under palliative care (e.g., metastatic cancer, cirrhosis, end-stage renal disease). * Severe multiorgan failure with expected survival \<7 days. * Conditions requiring prolonged mechanical ventilation (e.g., Guillain-Barré syndrome, cervical spinal cord injury). * Contraindications to hypercapnia (e.g., elevated intracranial pressure, acute coronary syndrome). * Prior use of advanced respiratory therapies (e.g., ECMO, inhaled nitric oxide, prone positioning, high-frequency ventilation). * Pregnancy, breastfeeding, or skin lesions at electrode placement sites. * Implanted electrical devices interfering with EIT (e.g., pacemaker, ICD). * Known allergy to electrode materials. * Refusal to participate or concurrent enrollment in another study
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What it tests

  • EIT-giuded PEEP
  • Control
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Where

1 site
Center for Anesthesia and Surgical Intensive Care, Viet Duc University Hospital
Hanoi, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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