Endoscopic Full Thickness Suturing of Mucosal, Submucosal and Perforation Defects Using Su2ura® GI System

Inclusion Criteria: 1. Age ≥18 years 2. Patient is able to provide informed consent . 3. Body mass index (BMI) 20-40 kg/m2 4. Patient is referred for endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) of a gastric neoplastic lesion 5. Candidate for endoscopic defect closure based on the operating's endoscopist assessment. Exclusion Criteria: 1. Patient with severe comorbidities likely to limit survival to less than 2 years. 2. Patients with INR\>1.5 3. Patients with PLT\< 150 4. Patient with known collagen or connective tissue disorders (e.g. scleroderma, marfan syndrome) . 5. Pregnant women or those intending to become pregnant during the study period 6. Patient with ascites on physical examination or CT scan. 7. Patient with varices. 8. Patient on peritoneal dialysis. 9. Patient with wound-healing disorders. 10. Patient with significant coagulation disorders or those requiring anti thrombotic or anticoagulation treatment other than aspirin . 11. Patient with autoimmune disorder requiring more than 10 mg of corticosteroid daily . 12. Patients in need of immunomodulatory therapy. 13. Immunocompromised patients (e.g., HIV/AIDS, organ transplant, chemo- or radiation therapy 6 months prior to recruitment). 14. Patient in need of concomitant surgical procedures other than those permitted in the protocol. 15. Non-compliance with the study protocol. 16. Patient requests to exist the study. -