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Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets

RecruitingNAAges 18 Years - 35 YearsAllJordan University of Science and Technology
NCT07318298 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars. Various biomaterials have been investigated to enhance wound healing and reduce postoperative morbidity. Hyaluronic acid (HA) has demonstrated anti-inflammatory and regenerative properties that may improve both soft and hard tissue healing. The aim of this study is to evaluate the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. A prospective, randomized, controlled clinical trial with a split-mouth design will be conducted. Twenty patients requiring bilateral mandibular third molar surgical extraction will be enrolled. In each patient, one extraction socket will receive hyaluronic acid combined with a collagen sponge, while the contralateral so

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📋 Eligibility rules (as published)
Inclusion Criteria: Male and female participants aged 18 to 35 years Presence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B Classified as American Society of Anesthesiologists (ASA) Physical Status I Absence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia) Ability to maintain adequate oral hygiene Ability to understand and provide written informed consent Ability to read and understand Arabic or English Willingness to comply with study procedures and follow-up visits Exclusion Criteria: History of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions Presence of severe or chronic illness requiring frequent hospitalization Pregnant or breastfeeding individuals History of cognitive or motor impairment that may interfere with study participation Use of anti-inflammatory or analgesic medications within two weeks before surgery Known allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) Current smoker Use of anticoagulant therapy Any condition that, in the investigator's judgment, may interfere with healing or study outcomes
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What it tests

  • Surgical extraction of wisdom teeth
  • bone biobsy
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Where

1 site
Higher specialty training center
Irbid, Jordan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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