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Personalized Atrial Fibrillation Ablation Guided by Non-Invasive Global Mapping

RecruitingNAAges 18 Years - anyAllGerman Heart Institute
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In plain words

What the trial is, and whether it could suit you

This pilot study investigates if non-invasive global mapping can guide catheter ablation of atrial fibrillation (AF) by defining personalized targets based on the temporal Stability of local Atrial High-Rate Activity (SAHRA). The study also assesses efficacy and safety of this approach and evaluates potential signals of harm. The main questions it aims to answer are: * Does ablation of targets defined by non-invasive global mapping improve rates of acute atrial fibrillation termination? * Does such a personalized ablation approach reduce arrhythmia recurrence rates? Researchers will compare the results of the personalized ablation approach with comparable patients that had undergone a conventional "empirical" ablation approach (pulmonary vein isolation). Participants will: * Undergo a personalized catheter ablation approach employing both a non-invasive global mapping system and a con

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📋 Eligibility rules (as published)
Inclusion Criteria: Ablation-naïve patients with: 1. Persistent AF planned for catheter ablation plus 2. Left atrial enlargement (LA diameter ≥45 mm or LA volume index ≥35ml/m2 or LA area ≥20 cm2) Exclusion Criteria: * Previous cardiac ablation * Age \<18 years * Pregnancy or lactation * Previous stroke/TIA * Severe left ventricular dysfunction (LVEF \<35%) * Renal failure (GFR \<30 ml/min) * Dermal disease or hypersensitivity predisposing for skin irritation or exanthema
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What it tests

  • Non-invasive mapping-guided ablation
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Where

5 sites
German Heart Center of the Charité, Charité University Hospital Berlin
Berlin, Germany
Frankfurt University Heart and Vascular Center
Frankfurt am Main, Germany
Central Lisbon University Hospital Centre (CHULC), Hospital de Santa Marta
Lisbon, Portugal
Hospital Clinic, University of Barcelona
Barcelona, Spain
Gregorio Marañón General University Hospital
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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