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Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease

RecruitingNAAges 50 Years - 90 YearsAllFujian Medical University Union Hospital
NCT07324161 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is grounded in the regulatory mechanisms of the glymphatic system and applies repetitive transcranial magnetic stimulation (rTMS) to the treatment of Alzheimer's disease (AD). The clinical efficacy and safety of rTMS will be systematically evaluated. Furthermore, transcranial magnetic stimulation-evoked potentials (TMS-EEG) and functional near-infrared spectroscopy (fNIRS) will be employed to investigate, from the perspectives of synaptic plasticity and neurovascular coupling, the mechanisms by which rTMS influences glymphatic function. Collectively, this work aims to provide new insights into both the therapeutic effectiveness and the underlying mechanisms of rTMS in AD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Meets the 2018 NIA-AA diagnostic criteria for Alzheimer's disease (AD) * Meets DSM-5 diagnostic criteria * Mild to moderate disease severity (CDR Global Score 1 to 2) * Evidence of AD pathology: positive amyloid PET OR positive cerebrospinal fluid (CSF) AD biomarkers OR positive plasma AD biomarkers Exclusion Criteria: * Contraindications to rTMS treatment * Severe complications or immune diseases * Unable to cooperate with study procedures * History of epilepsy
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What it tests

  • rTMS
  • sham rTMS
  • Accelerated rTMS
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Where

1 site
rTMS
Fuzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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