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The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Myocardial Deformation

Recruitingn/aAges 18 Years - 75 YearsAllUniversity of Athens
NCT07324902 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

1. Introduction Lipoprotein(a), or Lp(a), is a type of lipoprotein that is structurally similar to LDL (low-density lipoprotein) but carries an additional protein called apolipoprotein (a). 2. Purpose of the Study The primary purpose of this study is to investigate the effect of Lp(a) levels on arterial stiffness, endothelial function, and left atrial (LA) and left ventricular (LV) deformation over a 12-month follow-up period. Secondarily, the study will investigate: * a) The incidence of major adverse cardiovascular events (MACE), including cardiovascular death, acute myocardial infarction, and acute stroke. * b) The correlation between MACE incidence and parameters of arterial stiffness, endothelial function, and LA/LV deformation. * c) The levels of oxidative load markers. 3. Materials and Methods This observational study will include adults aged 18-75 years (regardle

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults participants 18-75 years old * Willing to sign the informed consent and paerticipate in the study Exclusion Criteria: * History of autoimmune/autoinflammatory disease, * Severe valvular heart disease, * severe chronic kidney disease(eGFR\<60 ml/min/1.73 m2), * Active Pregnancy * Severe hepatic impairment.
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What it tests

  • Not listed
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Where

2 sites
"Attikon" University General Hospital
Athens, Greece
Attikon University Hospital, 2nd Department of Cardiology, National and Kapodistrina University of Athens
Athens, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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