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โ† Trials
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Tonic Pain and Transauricular Vagal Nerve Stimulation

RecruitingNAAges 16 Years - 60 YearsAllAalborg University
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In plain words

What the trial is, and whether it could suit you

This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception. Primary outcomes include pain intensity. Secondary outcomes include sensory thresholds, resting heart rate (EKG), pupillary measurements and conditioned pain modulation.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Healthy * Speak and understand English * 18-60 years old. Exclusion Criteria: * Pregnant and/or breastfeeding * Regular use of cannabis, opioids or other drugs * Current or previous neurologic, musculoskeletal, mental, or other illnesses (e.g., brain or spinal cord injuries, degenerative neurological disorders, major depression, cardiovascular disease, chronic lung disease, etc.) * Current regular (once or more a week) use of analgesic medication or other medication which may affect the trial (including paracetamol and NSAIDs) * Recent history of acute pain particularly in the lower limbs * Abnormally disrupted sleep in 24 hours preceding experiment * Contraindications to electric stimulation application (history of epilepsy, metal implants in head or jaw, etc.) * Lack of ability to cooperate * Contraindications for capsaicin including an intolerance chili consumption and burns or wounds to the application site.
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What it tests

  • taVNS
  • Earlobe Stimulation
  • Sham (No Treatment)
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Where

1 site
Center For Neuroplasticity and Pain
Aalborg, Denmark
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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