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Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

RecruitingNAAges 6 Years - 21 YearsAllChildren's Hospital Medical Center, Cincinnati
NCT07325175 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

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📋 Eligibility rules (as published)
Inclusion Criteria: * For dystonia subjects: * Dx of dystonia (with and without DBS) * willingness and ability to complete study protocols. * For Typically Developing Controls: * normal developmental milestones * absence of any neuropsychiatric disorder * no significant medical condition. Exclusion Criteria: * history of epilepsy * presence of implanted medical devices (except DBS in dystonia subjects) * lack of cognitive or physical ability to complete study protocol.
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What it tests

  • DBS
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Where

1 site
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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