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Effect of Hydroxyapatite Toothpaste and Mouthwash in Preventing White Spot Lesions During Orthodontic Treatment

RecruitingNAAges any - anyAllHeba Tahseen Almasri
NCT07325643 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the effect of hydroxyapatite-containing toothpaste and mouthwash in preventing white spot lesions in patients undergoing orthodontic treatment. Participants: 75 patients will be divided into three groups: * Group A: Participants will brush their teeth three times a day using hydroxyapatite toothpaste and rinse twice a day with a placebo mouthwash. * Group B: Participants will brush their teeth three times a day using fluoride toothpaste and rinse twice a day with hydroxyapatite mouthwash. * Group C (Control Group): Participants will brush their teeth three times a day using fluoride toothpaste and rinse twice a day with a placebo mouthwash. Patients will be followed during their orthodontic treatment to assess the development of white spot lesions. The study is safe and involves no surgical procedures or risky medications, and will be conducted under the s

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📋 Eligibility rules (as published)
Inclusion Criteria: All included participants will be drawn from those who will receive comprehensive orthodontic treatment and fulfill the following inclusion criteria: 1. Complete permanent dentition up to the first premolar, with no intended extractions in orthodontic treatment plan. 2. Good overall health. 3. Good oral hygiene: full-mouth plaque score \< 20%. 4. No bleeding upon probing after 30 seconds. 5. Discontinuous band of plaque at the gingival margin. 6. Normal stimulated salivary flow rate. 7. Normal buffer capacity (final pH between 6.0 and 7.0) - Exclusion Criteria: * 1\. History of previous orthodontic treatment. 2. Bleaching or topical fluoridation within the last six months. 3. Severely rotated any of the study teeth (limiting the appearance of facial surfaces). 4\. Visible signs of caries, fluorosis, hypocalcification, or other developmental defects. 5. Restoration on the labial surface of the study teeth. 6. Systemic or endocrine conditions (e.g., cardiac pacemakers, diabetes mellitus). 7\. Craniofacial anomalies and clefts.
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What it tests

  • Hydroxyapatite Toothpaste
  • Hydroxyapatite Mouthwash
  • Fluoride Toothpaste + Placebo Mouthwash
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Where

1 site
University of Baghdad - College of Dentistry / Orthodontic Clinic
Baghdad, Iraq
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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