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Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation

Recruitingn/aAges 18 Years - 80 YearsAllMarmara University
NCT07325773 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation. In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults aged 18 to 80 years Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia. ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement Exclusion Criteria: * Patients undergoing pneumonectomy * Patients with renal, hepatic, or cardiovascular failure * Patients with a BMI \< 15 kg/m² or \> 35 kg/m² * Patients with a preoperative pulmonary function test showing FEV₁ \< 1.5 liters * Patients who are transferred to the intensive care unit intubated in the postoperative period * Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
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What it tests

  • Not listed
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Where

1 site
Marmara University Faculty of Medicine, Basibuyuk Campus
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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