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Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial

RecruitingNAAges 65 Years - anyAllSixth Affiliated Hospital, Sun Yat-sen University
NCT07328958 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Elderly patients are frequently burdened with age-associated comorbidities and frailty, accompanied by physiological changes such as vascular stiffening, cardiac dysfunction, and impaired autonomic regulation. These factors not only increase the risk of adverse perioperative outcomes but also heighten sensitivity to anesthetic agents, making elderly patients particularly susceptible to anesthesia-related complications, especially hypotension. Consequently, optimizing anesthesia strategies for this high-risk population has become a critical goal in perioperative management. Titrated anesthesia, which individualizes anesthetic drug delivery based on patient response to achieve predefined endpoints, offers a potential approach to mitigating anesthetic risks. Ciprofol, a novel intravenous anesthetic, has been associated with less hemodynamic suppression compared with traditional agents; how

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥65 years, scheduled for elective laparoscopic abdominal surgery * American Society of Anesthesiologists (ASA) physical status I-III * Requirement for invasive arterial blood pressure monitoring Exclusion Criteria: * Participation in other clinical trials that may interfere with the intervention or outcomes of this study * Severe hepatic or renal disease (GFR ≤30 mL/min/1.73 m², requirement for renal replacement therapy, or Child-Pugh class C liver function) * Uncontrolled severe hypertension (preoperative SBP ≥180 mmHg or DBP ≥110 mmHg) * Patients with severe mental disorders (such as schizophrenia), epilepsy, or Parkinson's disease, severe cognitive or intellectual impairment, severe visual or hearing impairments affecting assessment, or long-term alcohol abuse or use of sedative/analgesic medications; * Known allergy to drugs used in this study * Requirement for continuous vasopressor infusion before surgery, or intraoperative need for prolonged hemodynamic manipulation due to surgical factors * Anticipated blood loss \>15% of estimated blood volume * Expected surgical duration \<1 hours or \>6 hours * Expected postoperative hospital stay \<72 hours
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What it tests

  • titrated anesthesia
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Where

2 sites
Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, China
Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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