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Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury

Recruitingn/aAges 18 Years - 65 YearsAllTamas Vegh, MD
NCT07329595 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples. Under standard nutritional protocols and intensive care management, serial fecal sampling is performed to assess alterations in microbiome diversity and composition, as well as the indirect effects of these changes on measurable inflammatory biomarkers, endocrine, hematological, immunological, and other organ-specific parameters, the clinical course, and patient outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (age between 18 and 65 years) meeting the diagnostic criteria for severe burn injury, burns involving more than 20% of the total body surface area (TBSA) and/or inhalation injury. * Burn injury caused by scalding, flame, electrical, contact, or chemical exposure * Hospital admission within 24 hours following injury Exclusion Criteria: * Patients with inflammatory bowel diseases or malignant neoplasms. * Patients with a history of major gastric and/or intestinal resections * Patients in a pre-injury ECOG performance status of 4.
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What it tests

  • Not listed
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Where

1 site
University of Debrecen, Department of Anesthesiology and Intensive Care
Debrecen, Hungary
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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