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External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery

RecruitingNAAges 18 Years - 85 YearsAllJun Zhang
NCT07331441 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Postoperative pain after laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) is often severe, and inadequate analgesia may lead to increased opioid use, opioid dependence, and poor functional recovery. Current analgesic techniques such as neuraxial block have safety concerns (e.g., hypotension, neurological injury), while transversus abdominis plane (TAP) block is ineffective for blocking the lateral cutaneous branches of intercostal nerves in the upper abdomen. The External Oblique Intercostal Plane Block (EOIB) is a novel regional block technique that has shown promise in reducing postoperative opioids and pain in small-scale studies, but evidence for its use in major upper abdominal surgery is limited. This randomized controlled trial (RCT) aims to evaluate the analgesic efficacy and safety of bilateral EOIB combined with standard multi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Obtain written informed consent from participants or their legal representatives * Age between 18 and 85 years * American Society of Anesthesiologists (ASA) physical status classification I-III * Scheduled for elective laparoscopic major upper abdominal surgery (e.g., gastric, hepatic, gallbladder, pancreatic surgery) * Expected surgical duration ≥ 2 hours * Ability to use the intravenous patient-controlled analgesia (IV PCA) system Exclusion Criteria: * Hepatic disease (liver enzyme levels ≥ 2× the upper limit of normal) * Renal disease (serum creatinine levels ≥ 2× the upper limit of normal) * Allergy to local anesthetics or known study-related drugs * Pregnancy or lactation * Low surgical incision site (not involving the upper abdominal wall innervated by T6-T10 nerves) * Coagulopathy or current use of anticoagulant medications * Opioid use for more than 2 weeks in the past 6 months
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What it tests

  • External Oblique Intercostal Plane Block
  • Standard multimodal analgesia
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Where

1 site
Fudan University Shanghai Cancer Center
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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