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A Mixed Cohort, Multicentre Exploratory Study of Non-invasive Quantitative Assessment of Renal Graft Function With Non-contrast Functional Magnetic Resonance Imaging

Recruitingn/aAges 18 Years - anyAllTongji Hospital
NCT07333495 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical study aims to investigate a new, non-invasive method for monitoring kidney function after transplantation. Currently, assessing the health of a transplanted kidney often relies on blood tests or invasive biopsies, which may not detect subtle early changes or account for each kidney's unique starting point. This research will use advanced, non-contrast Magnetic Resonance Imaging (MRI) scans to measure various aspects of kidney health, such as blood flow and oxygen levels. The study includes two main groups of participants: 1) kidney transplant donors and their matched recipients, and 2) transplant recipients whose donors are unavailable for study (e.g., deceased donors). For donor-recipient pairs, the goal is to create a personalized "baseline" for each transplanted kidney by scanning the donor before donation. This allows doctors to compare the kidney's function after tra

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📋 Eligibility rules (as published)
Inclusion Criteria: Adult participants (age ≥ 18 years). For the Paired Donor-Recipient Cohort: Donor: Scheduled for living kidney donation, OR is a deceased organ donor who can undergo a pre-transplant MRI. Recipient: Recipient of a kidney transplant or simultaneous pancreas-kidney transplant from the paired donor. For the Independent Recipient Cohort: Recipient: Recipient of a kidney transplant from a deceased donor for whom donor baseline data is unavailable. Able to provide informed consent. Exclusion Criteria: Any contraindication to MRI (e.g., cardiac pacemaker, non-MRI compatible metallic implants, neurostimulators, severe claustrophobia). Inability to tolerate the breath-holding required for MRI acquisition. Pregnancy. Any clinical condition that, in the investigator's judgment, would severely compromise study participation or data integrity (e.g., uncontrolled severe infection, active major psychiatric illness).
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What it tests

  • Not listed
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Where

3 sites
Sinopharm Dongfeng General Hospital, Dongfeng Motor Corporation and Hubei University of Medicine.
Shiyan, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University
Taiyuan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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