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Detection of Minimal Residual Disease Post-prostatectomy

Recruitingn/aAges 18 Years - anyMaleRadboud University Medical Center
NCT07334275 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The clinical objective for this pilot study is to determine whether minimal residual disease (MRD) detection in high-risk prostate cancer, utilizing a custom-made prostate-specific circulating tumor DNA (ctDNA) panel, may lead to more optimal prediction of disease recurrence following radical prostatectomy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male aged 18 years or older; * High-risk prostate cancer, defined as: 1. High-risk localized prostate cancer, with PSA level \>20 ng/mL, Gleason score 8-10 (ISUP grade 4/5) at prostate biopsies, or iT3a (based on multi-parametric MRI of the prostate); or 2. High-risk locally advanced prostate cancer, having any PSA level, any Gleason score/ISUP grade, iT3b-4 (based on multi-parametric MRI of the prostate) or iN1 (based on PSMA PET/CT imaging); * Scheduled for robot-assisted radical prostatectomy; * Willingness to consent to both patient information sheets regarding tissue and liquid biobanking. Exclusion Criteria: * Relevant contra-indications that may limit clinical follow-up or blood collection, as assessed by the including physician.
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What it tests

  • Not listed
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Where

1 site
Prosper Prostate Cancer Clinics
Nijmegen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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