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Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Strasbourg, France
NCT07335627 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Clindamycin is an antibiotic with several advantages: high oral bioavailability and good bone and joint penetration. In France, it is a recommended drug for other types of Streptococcus spp. osteoarticular infections and can be used as an alternative to amoxicillin for periprosthetic infections, including when implants are retained. The hypothesis of this study is that clindamycin is no less effective than other drugs commonly used to treat periprosthetic Streptococcus spp. infections. The primary objective of this study is to evaluate the success rate of Streptococcus spp. periprosthetic joint infections treated with clindamycin compared to other antibiotic treatments.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patient (aged 18 years or older) at the time of surgery for infection * Probable or proven periprosthetic infection with Streptococcus spp. according to EBJIS diagnostic criteria * Patient operated on in one of the associated centers between 2013 and 2024 Exclusion Criteria: * Patient who underwent joint resection or amputation * Patient who was treated with suppressive antibiotic therapy (defined as antibiotic treatment lasting more than 6 months) which was decided upon prior to surgery
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What it tests

  • Not listed
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Where

1 site
Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France
Strasbourg, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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