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Topical Cryotherapy and Keloid/Hypertrophic Scars

RecruitingPhase 3Ages 18 Years - anyAllSonal Choudhary
NCT07336368 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether the application of brief topical cryotherapy immediately before intralesional corticosteroid injections can reduce pain and injection resistance during routine treatment of keloid and hypertrophic scars in adult patients. The main questions it aims to answer are: Does topical cryotherapy applied before intralesional triamcinolone injection impact pain perceptions for participants with keloids or hypertrophic scars? Does topical cryotherapy affect provider-assessed injection resistance compared with standard injection alone? Researchers will split the keloid/hypertrophic scar into two halves. One half will be treated with cryotherapy followed by steroid injection, while the other half will be treated with steroid injection alone to evaluate differences in pain perception and injection resistance. Participants will rate pain afte

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults (≥18 years) with keloids or hypertrophic scars already scheduled to receive intralesional triamcinolone (TAC) as part of routine care. * At least one keloid or hypertrophic scar with two comparable regions (≥2 cm each) suitable for split-treatment. * Able to provide informed consent and complete pain assessments in English. Exclusion Criteria: * Keloid or hypertrophic scar located on the face (except earlobes), excluded for cosmetic reasons. * Prior treatment to the study-selected keloid/hypertrophic scar based on self-report. * Inability to complete study assessments due to cognitive or language barriers.
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What it tests

  • Cryotherapy with liquid nitrogen
  • Intralesional Triamcinolone 10 mg/ml
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Where

1 site
University of Pittsburgh
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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