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Fungal Empyema Thoracis

RecruitingNAAges any - anyAllUniversity of Health Sciences Lahore
NCT07337993 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Fungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species. It typically occurs in immunocompromised or debilitated patients and carries a high mortality rate. Conventional management involves systemic antifungal therapy and surgical decortication; however, many patients are unfit for surgery due to poor clinical status or multiple comorbidities. The use of local intrapleural antifungal therapy remains poorly studied. Objective: This study aims to evaluate the efficacy and safety of pleural lavage with voriconazole in patients with fungal empyema thoracis, both as a pre-surgical adjunct and as a palliative measure for patients who cannot undergo surgery. Methods: A prospective cohort study will be conducted at the Department of Thoracic Surgery, Services Hospital, Lahore. Patients diagnosed

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📋 Eligibility rules (as published)
Inclusion Criteria: * All age patients with confirmed fungal empyema thoracis. * Patients with adequate pleural drainage through an intercostal chest tube. * Patients receiving systemic antifungal therapy. * Patients either: 1. scheduled for surgical decortication but undergoing lavage as a preoperative adjunct, or 2. considered unfit for surgery and managed conservatively. Exclusion Criteria: * Bacterial empyema without fungal growth. * Known hypersensitivity to anti-fungals. * Severe hepatic impairment (Child-Pugh class C) contraindicating voriconazole. * Pregnancy or lactation. * Refusal to participate.
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What it tests

  • pleural lavage followed by surgery
  • Decortication
  • Conservative Arm
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Where

1 site
Services Hospital Lahore
Lahore, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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