ConvaVAC™ Ag+ Negative Pressure Wound Therapy System in Chronic Wounds

Inclusion Criteria: * A wound which is amenable to NPWT and is a VLU as defined by CEAP Classification of C6 or C6R * Wounds that are clean or contaminated * Wounds with at least one sign or symptom of infection * Wounds that in the opinion of the investigator would benefit from an antimicrobial dressing * ≥18 years old at the time of consent Exclusion Criteria: * Known sensitivities or allergies to components of the ConvaVAC™ Ag+ NPWT System * Ischemic wounds with necrotic tissue or eschar present that require sharp debridement * Wound is too small or too large based on wound dressing size (\> 0.5cm2 and \< 100cm2) * Wound depth \>7cm * Wounds requiring concomitant use of DuoDERM® gel, hydrogels, petroleum-based creams/ ointment-/gels per the opinion of the investigator * Active chemotherapy, radiation therapy, or immunotherapy for cancer or completed treatment within the last 3 months * Any active malignancy at site of dressing application * Exposed bone in target wound * Exposed blood vessels or nerves in target wound * Systemic infection and/or systemic inflammatory response syndrome (SIRS), sepsis * Cellulitis in target wound * Untreated deep tissue infection including but not limited to osteomyelitis, septic arthritis * Active Pregnancy * Subjects that in the opinion of the investigator are not suitable for enrollment * Vulnerable subjects as determined by ICH Harmonized Guideline, Good Clinical Practice E6(R2)