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Comparing the Efficacy of Oral Fluconazole Versus Oral Itraconazole in Treating Resistant Tinea Corporis

RecruitingPhase 4Ages 18 Years - 70 YearsAllUrooj Fatima
NCT07342153 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Tinea corporis (commonly called "ringworm of the body") is a skin infection caused by fungi that often becomes difficult to treat when it persists despite creams or other medicines. In recent years, many patients have developed infections that do not respond to routine antifungal treatments, which causes long-term itching, redness, and scaling of the skin. This study will test two commonly used oral antifungal drugs - fluconazole and itraconazole - in people with resistant tinea corporis. Adults aged 18-70 years who have had persistent disease for at least six months will be enrolled at the Dermatology Department of CDA Hospital, Islamabad. Participants will be randomly assigned to one of two groups. One group will receive itraconazole 200 mg once daily for four weeks, and the other group will receive fluconazole 150 mg every other day for four weeks. Neither group will know which medi

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults aged 18-70 years Male or female Clinical diagnosis of resistant tinea corporis, defined as persistent disease ≥6 months despite topical antifungal therapy Microscopic confirmation of fungal hyphae on KOH preparation of skin scrapings Exclusion Criteria: Prior use of oral antifungal therapy within the past 3 months Recent antibiotic treatment for superadded bacterial skin infection in the past 1 month Known immunosuppressive conditions (e.g., diabetes mellitus, malignancy) Current or recent use of immunosuppressive drugs Pregnant or lactating women
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What it tests

  • Itraconazole (200 mg)
  • Fluconazole 150 mg
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Where

1 site
CDA Hospital Islamabad
Islamabad, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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