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Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Strasbourg, France
NCT07343037 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with hepatocellular insufficiency and/or cirrhosis are at risk of developing invasive fungal infections, particularly in critical care settings. In international recommendations, voriconazole is positioned as the first-line treatment for invasive aspergillosis. However, this molecule-and the azole class of antifungals-is associated with frequent hepatic toxicity. Available since 2018, isavuconazole appears to be better tolerated in patients without pre-existing liver dysfunction. The aim of this study is to retrospectively evaluate the validity of the hscore in intensive care and resuscitation patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patient (≥18 years old) * Patient admitted to the intensive care unit at Hautepierre Hospital, Strasbourg University Hospital, between January 1, 2014, and December 31, 2024 * At least 3 biological signs of HLH: * ferritin \> 2000 ng/mL * triglycerides \> 1.5 g/L * at least one cytopenia (leukocytes ≤ 5000 G/L, platelets ≤ 110 G/L, hemoglobin ≤ 9.2 g/dL). Exclusion Criteria: Refusal to participate in the study
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What it tests

  • Not listed
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Where

1 site
Médecine intensive - Réanimation - CHU de Strasbourg - France
Strasbourg, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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