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Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study

RecruitingNAAges 18 Years - anyAllHEIDEGGER CP
NCT07343440 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based nutritional strategies. The study includes mechanically ventilated patients expected to remain in the ICU for more than 72 hours. The intervention group will receive nutritional targets based on measured resting energy expenditure using the QNRG+ device, with a gradual escalation of energy delivery following current ESPEN guidelines. The primary outcome is quality of life at 3 months post-ICU admission, assessed using the EQ-5D-5L. Secondary outcomes include functional recovery, muscle preservation, infection rates, and rehospitalization. This study is the first to assess the long-term impact of IC-guided nutrition on recovery and quality of life using a patient-ce

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📋 Eligibility rules (as published)
Inclusion Criteria: All patients admitted to the ICU with the following criteria: * ≥18 years old * On Mechanical Ventilation * Expected ICU length of stay \>72 hours Exclusion Criteria: * Refusal of the family or patient * Patient transferred from another ICU * Pregnant patient * Patient is planned for a withdrawal of care or is actively dying * Cognitive disorder before ICU * Patient is in jail * Patients already enrolled in the ongoing NutriPhyT trial
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What it tests

  • Indirect Calorimetry Group
  • Control Group - Formula-Based Group
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Where

3 sites
Geneva University Hospital
Geneva, Switzerland
GHOL
Nyon, Switzerland
Zürich University Hospitals
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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