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Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery

RecruitingNAAges 21 Years - 60 YearsAllTanta University
NCT07344467 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 21-60 years old. * Both sexes. * Patients of American Society of Anesthesiologists (ASA) physical status I \& II. * Undergoing elective spine surgery. Exclusion Criteria: * Patient refusal. * History of allergic reactions to melatonin or pregabalin. * Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block). * Patients with kidney disease with (plasma creatinine level \> 1.5mg/dl). * Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal). * Psychological and cognitive disorders; dementia; major depression. * Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.
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What it tests

  • Placebo capsule
  • Melatonin capsule
  • Pregabalin capsule
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Where

1 site
Tanta University
Tanta, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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