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A Comparison of Radical Prostatectomy and Precision Prostatectomy in Low- and Intermediate-risk Prostate Cancers.

RecruitingNAAges any - anyMaleHenry Ford Health System
NCT07348367 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prostate cancer (PCa) management for low- and intermediate-risk patients often involves radical prostatectomy (RP), which achieves oncologic control but is associated with significant functional impairments, such as erectile dysfunction (50-70%) and urinary incontinence (5-20%). To address these issues, precision prostatectomy (PP) has emerged as a novel surgical approach that preserves functional structures while removing \>90% of prostate tissue. PP is thought to provide superior functional outcomes with acceptable oncological control by preserving the capsule, seminal vesicle (SV), and the surrounding neuronal nitric oxide synthase (nNOS) producing nerves on the side opposite to the dominant nodule while maximizing prostatic tissue removal. Early reports of PP demonstrate promising functional outcomes, with 90% of patients retaining sexual potency (Sexual Health Inventory for Men \[S

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📋 Eligibility rules (as published)
Inclusion Criteria: * Prostate cancer patients receiving treatment at Henry Ford Health from the investigator or co-investigator who opt for surgery. * Prostate-specific antigen (PSA) ≤20 ng/mL * Clinical stage ≤cT2 * Dominant unilateral lesion with Gleason ≤4+3 on biopsy * No Gleason ≥4 contralaterally * Preoperative SHIM score ≥17 (with or without phosphodiesterase-5 inhibitor use) Exclusion Criteria: * • Androgen deprivation therapy within 6 months. * Nodal positive disease * Metastatic disease * Prior prostate cancer therapy (e.g., radiation, HIFU). * Significant comorbidities precluding surgery or life expectancy \<5 years as defined by the Prostate Cancer Comorbidity Index \[5\]. * Any previous cancer diagnosis.
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What it tests

  • Radical Prostatectomy
  • Precision Prostatectomy
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Where

1 site
Henry Ford Health
Detroit, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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