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Opioid-Sparing Joint Replacement

RecruitingPhase 3Ages 18 Years - anyAllEmory University
NCT07348627 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate whether an opioid-sparing postoperative pain regimen can reduce opioid consumption and maintain effective pain control in adults undergoing anterior total hip arthroplasty for osteoarthritis. The main questions it aims to answer are: * Does an opioid-limited regimen result in lower postoperative opioid use compared with a standard opioid prescription? * Does the opioid-limited regimen provide comparable or improved postoperative pain control and patient satisfaction?

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of hip osteoarthritis requiring primary arthroplasty * Scheduled to undergo anterior total hip arthroplasty (THA) * Able to comply with study procedures and follow-up visits * Able to provide informed consent Exclusion Criteria: * Concurrent significant injuries to other bones or organs * Local infection at or near the surgical site * Preoperative opioid use within 4 weeks prior to surgery * History of severe heart disease (NYHA Class II or higher), renal failure, or liver dysfunction * Chronic liver disease * Neurological or psychiatric conditions that may influence pain perception * Pregnancy * History of alcohol or medication abuse * Inability to take NSAIDs * Use of postoperative DVT prophylaxis other than aspirin 81 mg twice daily * Diabetes mellitus with HbA1c \> 8.0% * Diagnosis of chronic pain syndrome or fibromyalgia * Pain Catastrophizing Scale (PCS) score \> 29 * Any condition that, in the investigator's judgment, may interfere with adherence to study procedures or follow-up
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What it tests

  • Placebo
  • Oxycodone 5 mg
  • Multimodal Non-Opioid Analgesia
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Where

1 site
Emory University Orthopedics and Spine Hospital
Atlanta, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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