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Underdilated-stent Technique Improves Post-TIPS Encephalopathy

RecruitingNAAges 18 Years - 75 YearsAllThe Second Affiliated Hospital of Chongqing Medicโ€ฆ
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In plain words

What the trial is, and whether it could suit you

Transjugular intrahepatic portosystemic shunt (TIPS) is a critical therapeutic approach for managing esophagogastric variceal bleeding and refractory ascites in decompensated cirrhosis patients. To date, hepatic encephalopathy (HE) remains one of the most common complications following TIPS procedures, and prediction and prevention of post-TIPS HE have always been a hotspot in the field of hepatology. However, no reliable clinical studies have confirmed that any drug or intervention can effectively prevent the occurrence of HE episodes following TIPS, including lactulose and rifaximin. Underdilated strategy (UDS) was reported as an development technique proposed in recent years for TIPS procedures, which involves using a small-diameter balloon to dilate the puncture tract and subsequently implanted standard-diameter covered stent (e.g., 8 mm). This allows the stent to maintain a smaller

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Liver cirrhosis, defined by clinical manifestations, biochemical indicators, imaging examinations, or liver biopsy; * History of esophagogastric variceal bleeding, or refractory/recurrent ascites; * Intended to undergo TIPS treatment. Exclusion Criteria: * Non-cirrhotic portal hypertension; * Previous treatments that may affect portal pressure, such as TIPS or surgical procedures; * History of overt hepatic encephalopathy (West-Haven classification โ‰ฅ2); * Malignant tumors in advanced stages; * Concomitant irreversible heart, liver, kidney, or respiratory failure; * Unable or unwilling to sign the informed consent form.
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What it tests

  • 6mm balloon dilation
  • 8mm balloon dilation
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Where

2 sites
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, China
Qianjiang Central Hospital
Qianjiang, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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