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Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty

RecruitingPhase 4Ages 18 Years - anyAllRegion Skane
NCT07350252 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: -Undergoing primary unilateral total knee arthroplasty Exclusion Criteria: * Pregnancy * Coagulopathy or other bleeding disorder that precludes regional anesthesia * Allergy to local anesthetics * Inability to understand spoken and written Swedish * Unwillingness to participate in the study
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What it tests

  • Ropivacain 5 mg/ml + Clonidine
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Where

1 site
Department of Anaesthesiology, Trelleborg Hospital
Trelleborg, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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