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Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery

Recruitingn/aAges 0 Years - 16 YearsAllUppsala University
NCT07351149 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project aims to conduct an international, prospective, multicentre, observational study to determine the incidence of Postoperative Acute Kidney Injury (PO-AKI) in hospitalized children after noncardiac surgery. Urinary biomarkers are intended to be evaluated as predictors of PO-AKI in the same subjects. The study employs modern standardized classifications for AKI to comprehensively address the issue of PO-AKI in children. Describing the incidence and identifying risk factors for PO-AKI will play a crucial role in developing preventive strategies aimed at reducing associated mortality and morbidity. Furthermore, investigating the relationship between urinary biomarkers of renal injury and PO-AKI will provide valuable insights into assessing postoperative renal function in paediatric patients, especially when repeated blood sampling is not feasible.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Elective, urgent or emergency in-patient major non-cardiac surgical procedures performed under general anaesthesia with or without regional analgesia with a planned procedure duration of at least 60 minutes. * Paediatric patients (0-16 years old) Exclusion Criteria: * Declined participation. * Ongoing renal replacement therapy * Acute Kidney Injury (according to KDIGO) * Known chronic kidney disease * Procedure involving surgery of the kidney * Procedures requiring clamping of blood flow to or from the kidney * Body weight \<2kg * Procedure involving contrast administration * Established rhabdomyolysis (CK-levels \>1500 U/L)
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What it tests

  • Not listed
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Where

16 sites
Perth Children's Hospital
Perth, Australia
The Kids Research Institute Australia
Perth, Australia
Hospital das Clínicas HCFMUSP
São Paulo, Brazil
Montreal Children's Hospital
Montreal, Canada
Children's Hospital Zagreb
Zagreb, Croatia
Hospices Civils de Lyon
Lyon, France
IRCCS Istituto Giannina Gaslini
Genova, Italy
Radboud UMC
Nijmegen, Netherlands

…and 8 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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