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Cardiac Magnetic Resonance for Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy

Recruitingn/aAges 16 Years - anyAllChinese Academy of Medical Sciences, Fuwai Hospit…
NCT07351838 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Non-dilated left ventricular cardiomyopathy (NDLVC), a newly defined cardiomyopathy subtype characterized by non-ischemic myocardial abnormalities without left ventricular dilation, poses challenges in prognosis assessment and risk stratification. This is a retrospective observational study aiming to explore the prognostic value of cardiac magnetic resonance (CMR) findings and identify key risk factors for adverse cardiovascular outcomes in patients with NDLVC. We will retrospectively enroll patients diagnosed with NDLVC who underwent CMR examination at the study institution during the predefined study period. CMR parameters, including left ventricular ejection fraction (LVEF), late gadolinium enhancement (LGE) patterns, myocardial strain, and the extent of myocardial fibrosis or fatty replacement, will be extracted and analyzed. The primary endpoint is a composite of major adverse card

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📋 Eligibility rules (as published)
Inclusion Criteria: * age ≥ 16 years; * indexed left ventricular end-diastolic volume (LVEDVi) \<96 mL/m2 in females and \<105 mL/m2 in males at baseline cardiac magnetic resonance (CMR); * either left ventricular ejection fraction (LVEF) \<50% and/or non-ischemic left ventricular (LV) scar/fatty replacement at baseline cardiac magnetic resonance. Exclusion Criteria: * lacked enhanced CMR images due to contraindications for receiving gadolinium contrast, such as severe renal disease; * ischemic heart disease, defined as stenosis of \>50% in a major epicardial coronary artery underwent coronary computed tomography angiography or coronary angiography, ischemic late gadolinium enhancement (LGE) pattern on CMR indicating prior infarction, or prior coronary revascularization; * abnormal loading conditions, defined as moderate to severe valvular heart diseases, congenital heart diseases, uncontrolled hypertension; * systemic rheumatologic diseases or sarcoidosis; * diagnostic criteria for other cardiomyopathies according to the European Society of Cardiology (ESC) definitions.
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What it tests

  • No intervention; Observational study
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Where

1 site
Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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