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Topical Diacerein in Psoriasis Vulgaris

RecruitingPhase 4Ages 18 Years - anyAllAlaa Ashraf Muhammad Helal
NCT07352306 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate the safety and effectiveness of topical diacerein in adults with psoriasis vulgaris. The primary objective of the study is to compare the proportion of participants who achieve a clinically meaningful improvement in disease severity between the topical diacerein group and the placebo group. Participants will: Be assigned to receive topical diacerein 1% or placebo twice daily for a treatment period of 2 months. Attend follow-up visits at Weeks 2, 4, 6, and 8. Undergo an additional evaluation one month after treatment cessation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years old of both genders. * Patients with mild chronic plaque psoriasis body surface area (BSA \< 10%) along with Psoriasis Area and Severity Index (PASI) score of \< 10, and/or Dermatology Life Quality Index (DLQI) score of \<10. Exclusion Criteria: * Documented hypersensitivity or idiosyncratic reaction to the investigational product or any excipients contained within the cream formulation. * Intake of anti-psoriatic systemic therapy within the last 3 months, or topical treatments within the last 2 weeks. * Patients with pustular psoriasis. * Pregnant and breast-feeding individuals. * Patients with psoriatic arthritis.
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What it tests

  • Diacerein
  • Placebo
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Where

1 site
Kasr Al-Ainy Psoriasis Unit
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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