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Effects of rTMS Combined With Dual-Task Gait Training on Walking and Cognition After Stroke

RecruitingNAAges 50 Years - anyAllThe Hong Kong Polytechnic University
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In plain words

What the trial is, and whether it could suit you

This randomized, double-blind, placebo-controlled trial will investigate whether repetitive transcranial magnetic stimulation (rTMS) applied to the dorsolateral prefrontal cortex (DLPFC) can enhance the effects of dual-task gait training in people with chronic stroke. Participants will be randomly allocated to receive either active rTMS or sham rTMS immediately before the same standardized dual-task gait training program. The intervention includes 12 sessions over 3 weeks. Outcomes will be assessed at baseline, immediately after training, and at 4-week follow-up. Co-primary outcomes are dual-task mobility and cognitive performance during walking, quantified using dual-task cost (DTC) for gait speed and cognitive-task performance during dual-task walking (e.g., Serial 7s; Shopping List Recall). Secondary outcomes include balance/mobility, community participation, mood/sleep measures, and

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Unilateral ischemic or hemorrhagic hemispheric stroke * Age โ‰ฅ 50 years -โ‰ฅ 6 months post-stroke * Medically stable * Able to walk independently โ‰ฅ 1 minute (assistive device allowed) * Able to follow commands * mRS 1-3 * MoCA โ‰ฅ 22 Exclusion Criteria: * Other neurological disorders * Cerebellar/brainstem injury * TMS contraindications (e.g., pacemaker, intracranial metal, seizure history, pregnancy) * Contraindications to exercise (e.g., unstable angina) * Severe aphasia (NIHSS item 9 โ‰ฅ 2) * Pain/illness limiting performance * Concurrent formal rehabilitation elsewhere * RMT cannot be determined * Fails TMS safety screening
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What it tests

  • active rTMS with dual-task training
  • sham rTMS with dual-task training
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Where

1 site
The Hong Kong Polytechnic University
Hong Kong, Hong Kong
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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