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Efficacies of Bismuth-amoxicillin-vonoprazan Triple Therapy and Bismuth Quadruple Therapy

RecruitingNAAges 18 Years - anyAllKaohsiung Medical University
NCT07358130 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

(1) To compare the efficacy and safety of a 14-day bismuth-amoxicillin-vonoprazan triple therapy versus a 14-day bismuth-based quadruple therapy as first-line treatments for H. pylori infection, and (2) To investigate the influence of H. pylori antibiotic resistance, along with host CYP3A4, CYP2C19, and IL-1B -511 genotypes, on the eradication efficacy of H. pylori therapies.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Subjects with Helicobacter pylori infection Exclusion Criteria: 1. Subjects with known hypersensitivity to the study drug. 2. Subjects with a history of gastric surgery. 3. Subjects with severe liver cirrhosis or uremia. 4. Subjects with a history of malignancy within the past five years. 5. Pregnant or breastfeeding women. 6. Subjects currently receiving treatment with atazanavir sulfate or rilpivirine hydrochloride.
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What it tests

  • vonoprazan, tripotassium dicitrate bismuthate, amoxicilline
  • rabeprazole, tripotassium dicitrate bismuthate, tetracycline, metronidazole
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Where

1 site
Kaohsiung Medical University Hospital
Kaohsiung City, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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